Recombinant Mouse Tissue Inhibitor of Metalloproteinases 2/TIMP-2 Protein(C-6His)

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Size

10µg

Price

267 EUR

Catalog no.

PKSM041160-10µg

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Activity

NA

AP Mol Mass

21kDa

Fusion tag

C-6His

Accession

P25785

Tissue

tissue

Mol Mass

22.5 kDa

Expressed Host

Human Cells

Sequence

Cys27-Pro220

Group

recombinants

Latin name

Mus musculus

Source

Recombinants or rec. proteins

Purity

>95% as determined by reducing SDS-PAGE.

Formulation

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,pH7.5.

Stability and Storage

Store at <-20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Synonym

TIMP-2; CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metalloproteinase inhibitor 2; Tissue inhibitor of metalloproteinase 2.

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.6

Background

Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.